Indanone scaffold play important role in the field of medicinal chemistry with so many pharmacological activities such as anti-inflammatory, anticonvulsants, antimicrobial, antiviral, antidiabetic and anticancer activity. The potency of these clinically useful drugs in treatment of microbial infections and other activities encouraged the development of some more potent and significant compounds. There has been considerable interest in development of a promising target for new drug development. Indanone is one such pharmacophore having different pharmacological activities. They are intermediates of many marketed drugs. A number of indanone scaffolds have been synthesized and evaluated for different biological activities. Here we have introduced different indanone scaffold which possess different biological activities depends on its types and position of substituted functional groups. This review is summarized to know about the chemistry of different indanone scaffold along with their pharmacological activities.
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